Researchers from Oregon State University (OSU) found that sulforaphane reduced the expression of long noncoding RNAs (lncRNAs) in prostate cancer cells, which disrupted the cells' ability to form colonies - a hallmark of metastatic cancer.
Previously believed to be "junk DNA" with no significant function, lncRNAs have increasingly emerged as key players in the development of numerous cancers, including prostate, breast, stomach, and lung cancers.
Studies have suggested that lncRNAs can regulate gene expression - the process by which genes are switched on or off in order to do their jobs. When lncRNAs become dysregulated, it is believed that they can fuel disease development.
Not only does the new study provide further evidence of the role lncRNAs play in cancer, but it supports previous research hailing the anticancer effects of sulforaphane.





