Drug extends life of younger women with advanced breast cancer, study says

Younger women suffering from a common form of advanced breast cancer have experienced significantly improved survival rates when treated with a drug that targets cancer cells, according to the findings of an international clinical trial.

The study was conducted among 672 women under the age of 59 who received a drug called palbociclib, in combination with a common form of hormone therapy.
Seventy percent of the women who took the combination therapy were alive after 42 months according to the findings, compared to 46% for women who were treated with only the hormone therapy and a placebo.
This, the researchers said, corresponded to a 29% lower risk of death in patients receiving the combination therapy.
The results were presented at the annual meeting of the American Society of Clinical Oncology in Chicago Saturday and will be published Tuesday in the New England Journal of Medicine.
The study is the first to show a significant benefit in survival for premenopausal women with metastatic hormone-receptor-positive breast cancer, according to lead author Dr. Sara Hurvitz, who directs the Breast Cancer Clinical Research Program at the UCLA Jonsson Comprehensive Cancer Center.

Rising suicide crisis: Adolescent mental health

Adolescence (10–19 years) is a unique and formative time. Whilst most adolescents have good mental health, multiple physical, emotional and social changes, including exposure to poverty, abuse, or violence, can make adolescents vulnerable to mental health problems. Promoting psychological well-being and protecting adolescents from adverse experiences and risk factors which may impact their potential to thrive are not only critical for their well-being during adolescence, but also for their physical and mental health in adulthood.

Mental health determinants
Adolescence is a crucial period for developing and maintaining social and emotional habits important for mental well-being. These include adopting healthy sleep patterns; taking regular exercise; developing coping, problem-solving, and interpersonal skills; and learning to manage emotions. Supportive environments in the family, at school, and in the wider community are also important.

The Coffin Salesman Trailer

The Coffin Salesman is a dark comedy about well...A coffin salesman who has hit hard times as sales have dipped drastically and he has to keep his family together while also taking care of his special needs child. Starring Kelechi Udegbe, Mariam Kayode, Gregory Ojefua, Harry Dorgu and Lolo Eremie. The Coffin Salesman is a story of love, family and you know...dying people.

U.S. Lawyer Who Perished on Crowded Everest Died ‘Doing What He Loved’

The 11th person to die on a crowded Mount Everest this climbing season was a Colorado lawyer who had just achieved his dream of reaching the top of the highest peak on each continent.

Christopher John Kulish, 62, was just descending from the summit when he died; the cause was unclear, but others have perished of altitude sickness at that level.

“He saw his last sunrise from the highest peak on Earth. At that instant, he became a member of the ‘7 Summit Club,’” his brother, Mark Kulish, said in a statement.

The brother said Kulish had been climbing for 50 years. “He passed away doing what he loved,” he said in the statement obtained by the Denver News. “We are heartbroken at this news.”

Kulish’s death came amid growing concerns about potentially fatal overcrowding on the mountain. This is the deadliest year on Everest since an avalanche in 2015 killed more than 22 people.

GODZILLA 2 Trailer 2019 Godzilla King Of The Monsters Movie HD

The Godzilla franchise is a Japanese kaiju media franchise featuring Godzilla, owned and created by Toho. It is recognized by Guinness World Records to be the longest continuously running movie franchise, having been in ongoing production from 1954 to the present day, with several hiatuses of varying lengths. Wikipedia

First film: Godzilla (1954)

Latest film: Godzilla: King of the Monsters (2019)

No. of films: 35

Genre(s): Kaiju; Tokusatsu; Monster; Science fiction; Fantasy; Horror

Rant Queens (Official Trailer Stereo)

“RANT QUEENS” – Synopsis
A Social Media War!
When a "meddling" mother clashes with
her "controversial" daughter in a series of rants,
the public goes agog asking for more…

*Edak Willie Productions* presents *"Rant Queens"*
* Starring:
Tana Adelana
MoyinOluwa Olutayo
Susan Peters
Jade Kosoko
Daniel K Daniel
Kunle Remi
Kunle Coker
Edak Willie

* Directed by Lancelot Imasuen
* Produced by MoyinOluwa Olutayo
* Assistant Director: Chris Orioha-Marcus
* DOP: Dele Ossai & Moses Joshua
* Written by: Patrick “Koinage” Nnamani
* Editor: Amen Imasuen
* Music Score: Daniel Tom
* Production Manager: Stephen Echendu
* Continuity: Seun Bamgbelu
* Executive Producer: Edak Willie
* Location: Lagos
* Year of Production: 2019
* Duration: 105minutes

* Rant Queens was produced by MoyinOluwa Olutayo for Edak Willie Productions

Over 3,000 People Line Up In The Rain To Give Boy With Leukemia A Chance At Life

It's natural for new parents to feel anxious about how things will turn out for their child. Most want the very best for their little ones, so they idea of them having trouble in school or experiencing bullying can be pretty worrying.

However, one of the worst–and fairly well-founded–fears is that they may have to deal with a life-threatening illness before they even get a chance to explore the many wonders that life has in store for them.

This is the situation that a boy in the U.K. now faces, but the outlook is good that it may soon be behind him.

The 'cultish sex circle' at centre of German crossbow massacre: Medieval-obsessed lesbian shot 'slave-master' in the heart in murder-suicide as pictures reveal his bizarre shop with a bloodstained mannequin, Knights Templar flag and weaponry

Germany's mysterious crossbow massacre, five deaths which have baffled police and enthralled the nation, revolved around a cultish sex circle with a focus on the Middle Ages, it was revealed today.

A macabre picture is emerging of the lives of those who died, at two locations, in what police believe is a grand murder-suicide between people who shared a passion for Medieval alchemy and weaponry.

The case so far revolves around Farina Caspari, 30, who was the last one alive before she turned a crossbow on herself and shot a bolt through her neck, and Torsten Weiss, 53, who has been described as a domineering figure who treated women 'like slaves' and ran a medieval-themed shop filled with weapons, Knights Templar flags and a blood-spattered mannequin on the counter.

Weiss appeared to have controlled the four women like a harsh sect leader who used physical force and psychological manipulation, Bild daily and RTL television reported.

New cinema has DOUBLE BEDS instead of seats (and don't worry if you're on the back row.

A new concept cinema has opened in Switzerland in which viewers recline in double beds rather than traditional seats.

The 'VIP bedroom' screen opened on Thursday inside Cinema Pathé in the northwesterly municipality of Spreitenbach near the Swiss-German border.

While they hope to entice fans of home-streaming services like Netflix and Amazon Prime, cinema operators waved away concerns about hygiene and inappropriate activity taking place during the screenings.

Venanzio Di Bacco, CEO of Pathé Switzerland, told local news website 20 minuten that the sheets will be changed between every single film, and that the design is tried and tested.

'The hygiene aspect is very important to us,' he said.

Teen beheaded classmate in jealous rage over girlfriend: prosecutors

A crazed teen beheaded a schoolmate who he thought had slept with his girlfriend, prosecutors said in court this week.

Mathew Borges was just 15 in November 2016 when he is accused of cutting off the head and hands of Lee Manuel Viloria-Paulino, 16, in Lawrence, Massachusetts.
Borges killed the Lawrence High School sophomore in a jealous rage after accusing him with sleeping with his girlfriend, causing them to split, prosecutors said in Essex County Superior Court on Monday, according to the Boston Herald.

“I think of killing someone and I smirk … It’s all I think about every day,” he texted the girl, according to Assistant DA Jay Gubitose.

“The next time you see me, look at my eyes because that’s the last time they’ll be like that. They’ll be dead,” he texted her before the brutal murder, according to the report.

2 killed, 4 injured in campus shooting at UNC Charlotte

Two people were killed and four others injured after a gunman opened fire in a classroom on a North Carolina college campus Tuesday afternoon.

The suspected shooter, identified by police as 22-year-old Trystan Andrew Terrell, was taken into custody after opening fire at the University of North Carolina at Charlotte, authorities said.

Terrell allegedly targeted a classroom on the campus at about 5 p.m., killing the two people and wounding four others — including three who were critically injured, authorities said.

Local media outlets reported he was a former student at the college who dropped out this year before completing his degree in history.

His grandfather told the Associated Press by phone on Tuesday night that he was shocked his grandson could be responsible for the slayings.

“This is not in his DNA,” Paul Rold of Arlington, Texas, said.

NIMBE MOVIE PREMIERE and AUDIENCE REVIEW

Hi Dear

I had the most fun on this day. I attended Nimbe movie premiere and I met a lot of amazing people. Watch and enjoy all the juice that happened at the premiere #nimbethemovie and Find out what the audience think about the movie... Thank you for watching... I am the realest Nigerian YouTuber. SUBSCRIBE, LIKE, SHARE...Please show me Love! Follow me on Social Media; Instagram: https://www.instagram.com/talk2urhommie/ Twitter: https://twitter.com/talk2urhommie Facebook: https://www.facebook.com/talk2urhommie Check out my blog: http://www.talk2urhommie.com/ And please, leave a comment for me Thanks YOU!

The 10 Thanos Comics You Should Read Before 'Avengers: Endgame'

fter a decade of building hype around the collection of six infinity MacGuffins, and a lot of doubt surrounding Thanos‘ ability to meet fandom’s expectation beyond that space chair he firmly planted himself upon, the Mad Titan finally decimated Earth’s Mightiest Heroes in Avengers: Infinity War. Whatever skepticism percolated in your brain as you walked out of the theater, in the moment, when Peter Parker ashed in the arms of Tony Stark, we were all balling at this impossible cliffhanger villain victory. What was all that fervor about the MCU’s antagonist problem? Solved? Malekith is still trash.

Five minutes into his big coming out party and Thanos was already slaying Asgardians and putting the Hulk in his corner. In a franchise built on protagonists persevering despite their failures, the gargantuan purple mo-cap monster delivered a catastrophic climax in which not only the costumed crusaders had to absorb, but the audience as well. The Russo Brothers twisted the knife even further when they closed the nightmare on a contented smile from the righteous maniac. Thanos won.

A year later, and we’re eagerly anticipating the big fix that will return Black Panther, Spider-Man, and the Guardians of the Galaxy to their billion dollar sequels. In a universe populated with Time Gems, Quantum Realms, and Captain Marvels, Phase 3 will not be the end of The Avengers. Duh. The mighty will return, and Thanos will have that smug smile wiped from his face. Of course, yes, we’re all worried about Steve Rogers. He sure does fetishize that sacrifice play.

'Stand By Me' is Stephen King's Most Personal Confrontation with Death

n 1986, a Stephen King novella, The Body (originally published in the Different Seasons anthology), was adapted into a feature film. This is not strange in itself — King is a prolific author, and his works have been adapted to film for decades — but while he is known as the King of Horror, this story was much more mundane.

Stand by Me, directed by Rob Reiner, is one of the best coming-of-age films ever to grace the big screen. It follows four boys’ end-of-summer adventure before they head off to junior high. They include Wil Wheaton as protagonist and narrator Gordie Lachance, River Phoenix as strong and sensitive group leader Chris Chambers, Corey Feldman as oddball Teddy Duchamp, and Jerry O’Connell as the begrudgingly included Vern Tessio.

They hear a rumor that the body of a missing boy has been seen not far from their hometown, Castle Rock. They decide that they must be the ones to find the body, and that finding and reporting it will make them town heroes. In a move that is incomprehensible by modern parenting standards, they lie to their parents about camping out in Vern’s field and disappear for almost two days to head off down the train tracks. Underneath the heartwarming quest that they undertake are some of King’s quintessential themes; death and grief underscore the journey.

When they first set out, the boys are giddy about their adventure. They sing, joke, and skip as they start down the train tracks. This walk in the woods provides a welcome distraction from their dysfunctional home lives, but it’s not long before their demons catch up with them. The first encounter with death occurs when a train comes along. Teddy stays on the tracks as the other three move clear because he wants to dodge the train. He stares down the locomotive as it approaches, and his friends don’t seem convinced that he will get out of the way in time. Teddy is furious with Chris for pulling him out of danger’s path. Chris apologizes and tells him that he can “dodge it later.”

NAF ESTABLISHES PIPE BAND, TO UPGRADE MUSIC SPECIALTY TO A FULL-FLEDGED DIRECTORATE

The Nigerian Air Force (NAF) today, 9 April 2019, graduated its first set of pipers at a colourful ceremony held at NAF Base, Bill Clinton Drive Abuja, which signaled the formal induction of the Pipe Band into the NAF. Twenty-five NAF personnel, comprising 22 airmen and 3 airwomen, successfully completed the course. The establishment of the Pipe Band, is in line with one of the key drivers of the Chief of the Air Staff (CAS), Air Marshal Sadique Abubakar’s Vision, that is; “human capacity development through robust and result oriented training for enhanced professional performance”. The Pipe Band is a key part of the full complement of military music systems, hence its induction will add glamour, aesthetics and pride to NAF ceremonies and events.